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KMID : 0061119840120000111
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Bulletin of the Clinical Research Institute
1984 Volume.12 No. 0 p.111 ~ p.111
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Time Course of UV-Induced Immune Suppression of DNCB Contact Hypersensitivity in Guinea Pigs
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Cho Gwang-Yoon
Houh Won
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Abstract
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The current experiment pursued the time course of UVB-induced immune suppression of DNCB contact hypersensitivity (CHS) in guinea pigs. Both group B and C, received suberythemal doses of UVB on days-3, -2´, -1, 0 and -6, -5, 4, -3, respectively, showed marked suppression so CHS (56.36% and 56.25%). However, the recovery of.CHS from the UVB-induced suppression started by group D (UVB on days -9, -8, -7, -6: 67.36%) and further extended to subsequent group E (UVB on days -12, -11, -10, -9: 78.82%). Group F (L VB on days -15, -14, -13, -12: 79.81%) and the final group G (UVB on days -18, -17, -16, -15: 81,94%) in which the recovery of CHS slightly exceeded the control ,(group A: 79.86%).
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KEYWORD
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